| Sempesserre | |
| Commune Status: | Commune |
| Arrondissement: | Condom |
| Canton: | Lectoure-Lomagne |
| Insee: | 32429 |
| Postal Code: | 32700 |
| Mayor: | Philippe Blancquart[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Lomagne Gersoise |
| Coordinates: | 44.0167°N 0.65°W |
| Elevation M: | 160 |
| Elevation Min M: | 57 |
| Elevation Max M: | 210 |
| Area Km2: | 20.99 |
Sempesserre (in French pronounced as /sɑ̃pesɛʁ/; Languedocien: Sempessèrra) is a commune in the Gers department in southwestern France.