| Semiramide Appiano | |
| Birth Date: | 1464 |
| Birth Place: | Republic of Florence |
| Death Place: | Republic of Florence |
| Issue: | Pierfrancesco de' Medici Averardo de' Medici Laudomia de' Medici Ginevra de' Medici Vincenzo de' Medici |
| Noble Family: | Appiano-Aragona (birth) Medici (marriage) |
| Father: | Jacopo III Appiano, Prince of Piombino |
| Mother: | Battistina Fregoso |
| Birth Name: | Semiramide di Appiano di Aragona |
Semiramide Appiano of Aragon (1464 – 9 March 1523) was an Italian noblewoman, daughter of the Lord of Piombino Jacopo III Appiano and wife of Lorenzo di Pierfrancesco de' Medici. She was the niece of the famous Simonetta Vespucci, Botticelli's muse and Giuliano de' Medici's beloved.
Semiramide Appiani was born in Florence in 1464. She was the daughter of Jacopo III Appiano, Lord of Piombino and relative of the Aragonas of Naples (his mother was Colia de' Giudici, natural daughter of Alfonso V of Aragon), and of Battistina Fregoso,[1] [2] daughter of Genoa doge Battista Fregoso, sister of doge Pietro Fregoso and maternal half-sister of the famous Simonetta Vespucci, known for her beauty and alleged lover of Giuliano de' Medici.[3]
In 1478 Lorenzo de' Medici, Giuliano's older brother and Lord of Florence, arranged a betrothal between Giuliano and Semiramide, but the marriage was never held due to Giuliano's death on 26 April 1478 during the Pazzi conspiracy. As a result, in 1482, Semiramide was given instead in marriage to Lorenzo di Pierfrancesco de' Medici, a cousin of Lorenzo and his protégé. Five children were born from the marriage.[4]
Semiramide died in Florence on 9 March 1523 at fifty-eight age.
By her husband, Semiramide had three sons and two daughters:[5]