Bis(2-chloroethyl)selenide explained

Bis(2-chloroethyl)selenide is the organoselenium compound with the formula . As a haloalkyl derivative of selenium, it is an analogue of bis(2-chloroethyl)sulfide, the prototypical sulfur mustard used in chemical warfare. Bis(2-chloroethyl)selenide has not been used as a chemical warfare agent, however it is still a potent alkylating agent and has potential in chemotherapy.^{[1] [2] [3] [4] [5]}

See also

• Diethyl selenide
• O-Mustard

Notes and References

1. Kang SI, Spears CP . Linear free energy relationships and cytotoxicities of para-substituted 2-haloethyl aryl selenides and bis(2-chloroethyl) selenides . Journal of Medicinal Chemistry . 30 . 4 . 597–602 . April 1987 . 3560155 . 10.1021/jm00387a003 .
2. Kang SI, Spears CP . Phenyl selenones: alkyl transfer by selenium-carbon bond cleavage . Journal of Medicinal Chemistry . 33 . 6 . 1544–7 . June 1990 . 2342050 . 10.1021/jm00168a003 .
3. Kang SI, Spears CP . Structure-activity studies on organoselenium alkylating agents . Journal of Pharmaceutical Sciences . 79 . 1 . 57–62 . January 1990 . 2313578 . 10.1002/jps.2600790114 .
4. Hu X, Tian Z, Chen Y, Lu X . One-Pot Two-Step Approach to Selenides. Phase-Transfer Catalyzed Synthesis of ω-Hydroxyalkyl Selenides. . Synthetic Communications . 2000 . 30 . 3 . 523–529 . 10.1080/00397910008087348 . 94951635 .
5. Potapov VA, Kurkutov EO, Musalov MV, Amosova SV . Synthesis of bis(2-haloethyl) selenides by reaction of selenium dihalides with ethylene. . Russian Journal of Organic Chemistry . February 2014 . 50 . 2 . 291–292 . 10.1134/S1070428014020250. 97109063 .