| Sekgoma II | |
| King (Kgosi) of Bechuanaland, Ruler of the Bangwato people of central Botswana, Paramount Chief of the Bamangwato | |
| Reign: | 1923–1925 |
| Full Name: | Sekgoma II Khala |
| Predecessor: | Khama III |
| Successor: | Seretse II |
| Spouse: | Tebogo Kebailele |
| Issue: | 3 sons and 1 daughter by 3 wives |
| Royal House: | Khama |
| Father: | Khama III (1872, 1875–1923) |
| Mother: | Elizabeth MmaBessie |
| Birth Date: | 1869 |
| Birth Place: | Bechuanaland |
| Death Date: | 17 November |
| Death Place: | Mafikeng |
Sekgoma (or Sekhome) II (1869 – November 17, 1925) was the king of the Bamangwato people of Bechuanaland in modern-day Botswana.
He was the son of King Khama III by his first wife, Mma-Besi. In 1923, Sekgoma II ascended the throne at the age of 54 upon the death of his father. However, his reign was short and only lasted two years. Sekgoma's son, Seretse II, was too young at the time to ascend the throne, and Tshekedi Khama, Sekgoma's younger brother, acted as regent.