| Lac des Mille Lacs 22A2 | |
| Official Name: | Lac des Mille Lacs Indian Reserve No. 22A2 |
| Settlement Type: | Indian reserve |
| Pushpin Map: | Canada Ontario |
| Pushpin Mapsize: | 200 |
| Coordinates: | 49.0231°N -90.8922°W |
| Coordinates Footnotes: | [1] |
| Subdivision Type: | Country |
| Subdivision Type1: | Province |
| Subdivision Type2: | District |
| Subdivision Name2: | Thunder Bay |
| Subdivision Type3: | First Nation |
| Subdivision Name3: | Lac des Mille Lacs |
| Area Land Km2: | 31.28 |
| Population Footnotes: | [2] |
| Population Total: | 0 |
| Population As Of: | 2011 |
| Population Density Km2: | 0 |
Lac des Mille Lacs 22A2 (formerly Seine River 22A2) is a First Nations reserve in northwestern Ontario, Canada. It is one of the reserves of the Lac des Mille Lacs First Nation.