SCG2 explained

SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene.^[1]

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotactic effects on specific cell types, and EM66, whose function is unknown.^[2]

See also

• Chromogranin

Further reading

• Kirchmair R, Gander R, Egger M, etal . The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo. . Circulation . 109 . 6 . 777–83 . 2004 . 14970115 . 10.1161/01.CIR.0000112574.07422.C1 . free .
• Ozawa H, Takata K . The granin family--its role in sorting and secretory granule formation. . Cell Struct. Funct. . 20 . 6 . 415–20 . 1995 . 8825061 . 10.1247/csf.20.415 . free .
• Huttner WB, Gerdes HH, Rosa P . The granin (chromogranin/secretogranin) family. . Trends Biochem. Sci. . 16 . 1 . 27–30 . 1991 . 2053134 . 10.1016/0968-0004(91)90012-K .
• Stemberger K, Pallhuber J, Doblinger A, etal . Secretoneurin in the human aqueous humor and the absence of an effect of frequently used eye drops on the levels. . Peptides . 25 . 12 . 2115–8 . 2004 . 15572199 . 10.1016/j.peptides.2004.08.010 . 21826451 .
• Scammell JG, Reddy S, Valentine DL, etal . Isolation and characterization of the human secretogranin II gene promoter. . Brain Res. Mol. Brain Res. . 75 . 1 . 8–15 . 2000 . 10648883 . 10.1016/S0169-328X(99)00269-7 .
• Kähler CM, Schratzberger P, Kaufmann G, etal . Transendothelial migration of leukocytes and signalling mechanisms in response to the neuropeptide secretoneurin. . Regul. Pept. . 105 . 1 . 35–46 . 2002 . 11853870 . 10.1016/S0167-0115(01)00379-2 . 6144086 .
• Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F . Phosphoproteomic analysis of the human pituitary. . Pituitary . 9 . 2 . 109–20 . 2006 . 16807684 . 10.1007/s11102-006-8916-x . 10789246 .
• Lim J, Hao T, Shaw C, etal . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. . Cell . 125 . 4 . 801–14 . 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Kato A, Kammen-Jolly K, Fischer-Colbie R, etal . Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human brainstem. . Brain Res. . 852 . 2 . 444–52 . 2000 . 10678772 . 10.1016/S0006-8993(99)02229-5 . 22936622 .
• Schrott-Fischer A, Bitsche M, Humpel C, etal . Chromogranin peptides in amyotrophic lateral sclerosis. . Regul. Pept. . 152 . 1–3 . 13–21 . 2009 . 18721831 . 10.1016/j.regpep.2008.07.009 . 207494362 .
• Fischer-Colbrie R, Kirchmair R, Kähler CM, etal . Secretoneurin: a new player in angiogenesis and chemotaxis linking nerves, blood vessels and the immune system. . Curr. Protein Pept. Sci. . 6 . 4 . 373–85 . 2005 . 16101435 . 10.2174/1389203054546334 .
• Hillier LW, Graves TA, Fulton RS, etal . Generation and annotation of the DNA sequences of human chromosomes 2 and 4. . Nature . 434 . 7034 . 724–31 . 2005 . 15815621 . 10.1038/nature03466 . 2005Natur.434..724H . free .
• Lankat-Buttgereit B, Müller S, Schmidt H, etal . Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line. . Biol. Cell . 100 . 12 . 703–15 . 2008 . 18549351 . 10.1042/BC20080052 . 8007910 .
• Stridsberg M, Eriksson B, Janson ET . Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. . Regul. Pept. . 148 . 1–3 . 95–8 . 2008 . 18448176 . 10.1016/j.regpep.2008.03.007 . 24853860 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wen G, Wessel J, Zhou W, etal . An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. . Hum. Mol. Genet. . 16 . 14 . 1752–64 . 2007 . 17584765 . 10.1093/hmg/ddm123 . 2695823 .
• Yon L, Guillemot J, Montero-Hadjadje M, etal . Identification of the secretogranin II-derived peptide EM66 in pheochromocytomas as a potential marker for discriminating benign versus malignant tumors. . J. Clin. Endocrinol. Metab. . 88 . 6 . 2579–85 . 2003 . 12788858 . 10.1210/jc.2002-021748 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Wu C, Ma MH, Brown KR, etal . Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. . Proteomics . 7 . 11 . 1775–85 . 2007 . 17474147 . 10.1002/pmic.200601006 . 22474278 .
• Li L, Hung AC, Porter AG . Secretogranin II: a key AP-1-regulated protein that mediates neuronal differentiation and protection from nitric oxide-induced apoptosis of neuroblastoma cells. . Cell Death Differ. . 15 . 5 . 879–88 . 2008 . 18239671 . 10.1038/cdd.2008.8 . 205116721 .

Notes and References

1. Gerdes HH, Rosa P, Phillips E, Baeuerle PA, Frank R, Argos P, Huttner WB . The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation . J. Biol. Chem. . 264 . 20 . 12009–15 . July 1989 . 10.1016/S0021-9258(18)80167-3 . 2745426 . free .
2. Web site: Entrez Gene: SCG2 .