| Conflict: | Second expedition to Palembang |
| Place: | Palembang, Palembang Sultanate |
| Date: | 1821 |
| Result: | Dutch victory |
| Combatant1: | Netherlands |
| Combatant2: | Palembang Sultanate |
| Commander1: | Hendrik Merkus François de Stuers |
| Commander2: | Mahmud Badaruddin |
| Strength1: | 4,179 |
| Strength2: | Unknown |
| Casualties1: | 95 killed 220 wounded |
| Casualties2: | Unknown |
The second expedition to Palembang was a punitive expedition by the Dutch against the Palembang Sultanate in 1821. The commander of the expedition, Hendrik Merkus de Kock, succeeded in coming to an agreement with Sultan Mahmud Badaruddin II.