| Cabinet Type: | Ministry |
| Jurisdiction: | Maharashtra |
| Flag Border: | true |
| Date Formed: | 1 November 2004 |
| Date Dissolved: | 4 December 2008 |
| Government Head: | Vilasrao Deshmukh |
| State Head: | Governor - Mohammed Fazal (2004) S. M. Krishna (2004-08) S. C. Jamir (2008) |
| Members Number: | 27 Cabinet ministers Congress (8) NCP (17) Independents (2) |
| Political Parties: | Congress NCP Independents |
| Opposition Party: | Shiv Sena BJP |
| Opposition Leader: |
Narayan Rane (Shiv Sena) (2004-05) Nitin Gadkari (BJP) (2004-05) |
| Election: | 2004 |
| Legislature Term: | 5 years |
| Previous: | Shinde ministry |
| Successor: | First Ashok Chavan ministry |
Vilasrao Deshmukh of the Indian National Congress formed his second Maharashtra government after his party won the 2004 Maharashtra Legislative Assembly elections, in alliance with Nationalist Congress Party.[1] Deshmukh had previously served as the State's Chief Minister from 1999 to 2003.[2]
Deshmukh's initial cabinet included the following members:[3]
| Sr No. | District | Guardian_Minister | Party | |
|---|---|---|---|---|
| 01 | Ahmednagar | Balasaheb Thorat | United Progressive Alliance | |
| 02 | Akola | Vimal Mundada | ||
| 03 | Amravati | Jayant Patil | ||
| 04 | Aurangabad | Vijaysinh Mohite-Patil | ||
| 05 | Beed | Nawab Malik | ||
| 06 | Bhandara | Jayant Patil | ||
| 07 | Buldhana | Ashok Chavan | ||
| 08 | Chandrapur | Ashok Chavan | ||
| 09 | Dhule | Surupsingh Hirya Naik | ||
| 10 | Gadchiroli | R. R. Patil | ||
| 11 | Gondiya | Patangrao Kadam | ||
| 12 | Hingoli | Vasant Purke | ||
| 13 | Jalgaon | Suresh Jain | ||
| 14 | Jalna | Vijaykumar Krishnarao Gavit | ||
| 15 | Kolhapur | Patangrao Kadam | ||
| 16 | Latur | Surupsingh Hirya Naik | ||
| 17 | Mumbai City | Chhagan Bhujbal | ||
| 18 | Mumbai Suburban | Chandrakant Handore | ||
| 19 | Nagpur | Anil Deshmukh | ||
| 20 | Nanded | Ashok Chavan | ||
| 21 | Nandurbar | Manohar Naik | ||
| 22 | Nashik | Chhagan Bhujbal | ||
| 23 | Osmanabad | Balasaheb Thorat | ||
| 24 | Palghar | Harshvardhan Patil | ||
| 25 | Parbhani | Dilip Walse-Patil | ||
| 26 | Pune | Ajit Pawar | ||
| 27 | Raigad | Sunil Tatkare | ||
| 28 | Ratnagiri | Anees Ahmed | ||
| 29 | Sangli | R. R. Patil | ||
| 30 | Satara | Babanrao Pachpute | ||
| 31 | Sindhudurg | Vinay Kore | ||
| 32 | Solapur | Vijaysinh Mohite-Patil | ||
| 33 | Thane | Ganesh Naik | ||
| 34 | Wardha | Ganesh Naik | ||
| 35 | Washim | Anees Ahmed | ||
| 36 | Yavatmal | Ramraje Naik Nimbalkar | ||