| Second Presbyterian Church | |
| Location: | 801 Waller St., Portsmouth, Ohio |
| Coordinates: | 38.7364°N -82.9897°W |
| Built: | 1911 |
| Architect: | Kramer, George W. |
| Builder: | J.C. Fulton & Sons. et al |
| Architecture: | Late Gothic Revival |
| Added: | August 22, 1996 |
| Area: | less than one acre |
| Refnum: | 96000926 |
The Second Presbyterian Church in Portsmouth, Ohio is a historic church at 801 Waller Street.
It was built in 1911 and was a work of architect George W. Kramer.
It was added to the National Register of Historic Places in 1996. As of 2012 the congregation is affiliated with the Presbyterian Church (U.S.A.).[1]