| Cabinet Type: | Ministry |
| Jurisdiction: | Maharashtra |
| Flag Border: | true |
| Date Formed: | 1 November 2004 |
| Date Dissolved: | 4 December 2008 |
| Government Head: | Vilasrao Deshmukh |
| State Head: | Governor - Mohammed Fazal (2004) S. M. Krishna (2004-08) S. C. Jamir (2008) |
| Members Number: | 27 Cabinet ministers Congress (8) NCP (17) Independents (2) |
| Political Parties: | Congress NCP Independents |
| Opposition Party: | Shiv Sena BJP |
| Opposition Leader: |
Narayan Rane (Shiv Sena) (2004-05) Nitin Gadkari (BJP) (2004-05) |
| Election: | 2004 |
| Legislature Term: | 5 years |
| Previous: | Shinde ministry |
| Successor: | First Ashok Chavan ministry |
Vilasrao Deshmukh of the Indian National Congress formed his second Maharashtra government after his party won the 2004 Maharashtra Legislative Assembly elections, in alliance with Nationalist Congress Party.[1] Deshmukh had previously served as the State's Chief Minister from 1999 to 2003.[2]
Deshmukh's initial cabinet included the following members:[3]