Second Creek is a waterway in the southern section of Adams County, Mississippi, United States. Second Creek is tributary to the Homochitto River.[1] It enters the Homochitto near U.S. Route 61 bridge at Doloroso.[2]
The Spanish explorer Hernando de Soto visited what is called White Apple Village, the settlement of Natchez chief Great Sun, along Second Creek, in approximately 1541.[3] An attempted slave revolt, sometimes known as the Second Creek Slave Conspiracy, was suppressed in the vicinity of Second Creek in 1860.[4]