| Second Christian Church | |
| Location: | 401 N. 5th, Columbia, Missouri |
| Coordinates: | 38.9556°N -92.3319°W |
| Built: | 1927 |
| Architecture: | Eclectic |
| Added: | September 4, 1980 |
| Area: | less than one acre |
| Refnum: | 80002314 |
Second Christian Church is a historic African-American church located at 401 N. 5th, Columbia, Missouri. It was built in 1927, and is in an eclectic architectural style. It was added to the National Register of Historic Places in 1980.