| Cabinet Name: | Second Cabinet of Kostas Karamanlis |
| Jurisdiction: | Greece |
| Flag: | Flag of Greece.svg |
| Government Head: | Kostas Karamanlis |
| State Head: | Karolos Papoulias |
| Political Parties: | New Democracy (ND) |
| Opposition Parties: | Panhellenic Socialist Movement (PASOK) Communist Party of Greece (KKE) Coalition of the Radical Left (SYRIZA) Popular Orthodox Rally (LAOS) |
| Opposition Leader: | George Papandreou |
| Election: | 2007 Greek legislative election |
| Legislature Term: | 12th (2007–2009) |
| Previous: | Kostas Karamanlis I cabinet |
| Successor: | George Papandreou Cabinet |
Kostas Karamanlis served as a Prime Minister of Greece for two consecutive terms. During his incumbency, the period 2004-2009, he formed two cabinets. The second Kostas Karamanlis cabinet was formed after the 2007 elections and was succeeded by the George Papandreou Cabinet.
On September 18, 2007, after the re-election of his government, Prime Minister Kostas Karamanlis announced his second cabinet, the members of which assumed office on 19 September 2007.
As part of a reorganisation of the ministries, the incoming government announced:
On 7 January 2009, Karamanlis announced another major cabinet reshuffle.