| Cabinet Name: | Second Smuts Cabinet |
| Cabinet Number: | 4th |
| Jurisdiction: | the Union of South Africa (since the 1909 South Africa Act) |
| Flag: | Red Ensign of South Africa (1912–1951).svg |
| Flag Border: | true |
| Incumbent: | 1921–1924 |
| State Head Title: | Monarch |
| State Head: | King George V |
| Governor General Title: | Governor-General |
| Government Head Title: | Prime Minister |
| Government Head: | Jan Smuts |
| Political Party: | South African Party |
| Legislature Status: | Majority |
| Opposition Party: | National Party |
| Opposition Leader: | Barry Hertzog |
| Election: | 1921 election |
| Previous: | Smuts I |
| Successor: | Hertzog I |
| Post | Minister | Term | Party | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Prime Minister | Gen. Jan Smuts | 1919 | 1924 | align=center | SAP | ||||
| Minister of Agriculture | The Hon. Deneys Reitz MP | 1921 | 1924 | align=center | SAP | ||||
| Minister of Defence |
| 1919 | 1924 | align=center | SAP | ||||
| Minister of Education | The Hon. Patrick Duncan MP | 1921 | 1924 | align=center | SAP | ||||
| Minister of Finance |
| 1920 | 1924 | align=center | SAP | ||||
| Minister of Public Health | The Hon. Patrick Duncan MP | 1921 | 1924 | align=center | SAP | ||||
| Minister of Interior Affairs | The Hon. Patrick Duncan MP | 1921 | 1924 | align=center | SAP | ||||
| Minister of Justice |
| 1913 | 1924 | align=center | SAP | ||||
| Minister of Lands and Irrigation | The Hon. Deneys Reitz MP | 1921 | 1924 | align=center | SAP | ||||
| Minister of Mines and Industry |
| 1912 | 1924 | align=center | SAP | ||||
| Minister of Native Affairs | Gen. Jan Smuts | 1919 | 1924 | align=center | SAP | ||||
| Minister of Posts and Telegraphs |
| 1921 | 1924 | align=center | SAP | ||||
| Minister of Public Works |
| 1921 | 1924 | align=center | SAP | ||||
| Minister of Railways and Harbours |
| 1921 | 1924 | align=center | SAP | ||||