| Cabinet Name: | Second Verwoerd Cabinet |
| Cabinet Number: | 2nd |
| Jurisdiction: | the Republic of South Africa (since the 1961 Constitution) |
| Flag: | Flag of South Africa (1928–1982).svg |
| Flag Border: | true |
| Incumbent: | 1966 |
| Date Dissolved: | |
| State Head Title: | State President |
| State Head: | Charles Robberts Swart |
| Government Head Title: | Prime Minister |
| Government Head: | Hendrik Verwoerd |
| Political Party: | National Party |
| Legislature Status: | Majority |
| Opposition Party: | United Party |
| Opposition Leader: | De Villiers Graaff |
| Election: | 1966 election |
| Previous: | Verwoerd I |
| Successor: | Vorster I |
| Cabinet post | Minister | Start | End | |
|---|---|---|---|---|
| Prime Minister | 1 April 1966 | 6 September 1966 | ||
| Minister of Foreign Affairs | 1 April 1966 | 6 September 1966 | ||
| Minister of Defense | 1 April 1966 | 6 September 1966 | ||
| Minister of Finance | 1 April 1966 | 6 September 1966 | ||
| Minister of Interior | 1 April 1966 | 6 September 1966 | ||
| Minister of Justice Minister of Police | 1 April 1966 | 6 September 1966 | ||
| Minister of Transport | 1 April 1966 | 6 September 1966 | ||
| Minister of Labour Minister of Minorities | 1 April 1966 | 6 September 1966 | ||
| Minister of Mining | 1 April 1966 | 6 September 1966 | ||
| Minister of Economy | 1 April 1966 | 6 September 1966 | ||
| Minister of Bantu Administration and Development Minister of Bantu Education | M. C. Botha | 1 April 1966 | 6 September 1966 | |
| Minister of Public Works Minister of Social Security and Pensions | W. A. Maree | 1 April 1966 | 6 September 1966 | |
| Minister of Education, Arts and Science Minister of Information | 1. April 1966 | 6. September 1966 | ||
| Minister of Forestry, Tourism and Sport | Frank Waring | 1 April 1966 | 6 September 1966 | |
| Minister of Agricultural Credit and Land Administration | D. C. H. Uys | 1 April 1966 | 6 September 1966 | |
| Minister of Water and Agricultural Technical Services | 1 April 1966 | 6 September 1966 | ||
| Minister of Post and Telegraphy Minister of Health | 1 April 1966 | 6 September 1966 | ||
| Minister of Immigration Minister of Indian Affairs | Alfred Trollip | 1 April 1966 | 6 September 1966 |