| Cabinet Name: | Second Vorster Cabinet |
| Cabinet Number: | 4th |
| Jurisdiction: | the Republic of South Africa (since the 1961 Constitution) |
| Flag: | Flag of South Africa (1928–1982).svg |
| Flag Border: | true |
| Incumbent: | 1970–1974 |
| State Head Title: | State President |
| State Head: | Jacobus Fouché |
| Government Head Title: | Prime Minister |
| Government Head: | Johannes Vorster |
| Political Party: | National Party |
| Legislature Status: | Majority |
| Opposition Party: | United Party |
| Opposition Leader: | De Villiers Graaff |
| Election: | 1970 election |
| Previous: | Vorster I |
| Successor: | Vorster III |
| Prime Minister | Johannes Vorster | 18 May 1970 | 29 April 1974 | |
| Minister of Foreign Affairs | Hilgard Muller | 18 May 1970 | 29 April 1974 | |
| Minister of Defense | Pieter Willem Botha | 18 May 1970 | 29 April 1974 | |
| Minister of Finance | Nicolaas Diederichs | 18 May 1970 | 29 April 1974 | |
| Minister of Home Affairs | Marais Viljoen Theo Gerdener Connie Mulder | 18 May 1970 | 29 April 1974 | |
| Minister of Immigration | Connie Mulder Piet Koornhof | 18 May 1970 1972 | 1972 29 April 1974 | |
| Minister of Information | Connie Mulder | 18 May 1970 | 29 April 1974 | |
| Minister of Justice and Prisons | Petrus Cornelius Pelser | 18 May 1970 | 29 April 1974 | |
| Minister of Police | Lourens Muller | 18 May 1970 | 29 April 1974 | |
| Minister of Transport | Ben Schoeman | 18 May 1970 | 29 April 1974 | |
| Minister of Labour | Marais Viljoen | 18 May 1970 | 29 April 1974 | |
| Minister of Mining | Carel de Wet Piet Koornhof | 18 May 1970 | 29 April 1974 | |
| Minister of Sports and Recreation | Frank Waring Piet Koornhof | 18 May 1970 | 29 April 1974 | |
| Minister of the Economy | Lourens Muller | 18 May 1970 | 29 April 1974 | |
| Minister of Bantu Administration and Bantu Education | M. C. Botha | 18 May 1970 | 29 April 1974 | |
| Minister of National Education | Johannes van der Spuy | 18 May 1970 | 29 April 1974 | |
| Minister of Public Works | Blaar Coetzee Abraham du Plessis | 18 May 1970 | 29 April 1974 | |
| Minister of Agriculture | D. C. H. Uys Hendrik Schoeman | 18 May 1970 1972 | 1972 29 April 1974 | |
| Minister of Water Affairs and Forestry | Fanie Botha | 18 May 1970 | 29 April 1974 | |
| Minister of Welfare and Pensions | Connie Mulder Johannes van der Spuy | 18 May 1970 | 29 April 1974 | |
| Minister of Post, Telegraphs and Telecommunication | Marais Viljoen | 18 May 1970 | 29 April 1974 | |
| Minister of Health | Carel de Wet Schalk van der Merwe | 18 May 1970 1972 | 1972 29 April 1974 | |
| Minister of the Environment | Jannie Loots | 1973 | 29 April 1974 | |
| Minister of Planning and Statistics | Jannie Loots | 18 May 1970 | 29 April 1974 | |
| Minister of Tourism and Minister of Indian Affairs | Frank Waring Owen Horwood | 18 May 1970 1972 | 1972 29 April 1974 | |
| Minister of Coloured Affairs and Matters of the Rehoboth Homeland | Jannie Loots Schalk van der Merwe | 18 May 1970 1972 | 1972 29 April 1974 |