| Partof: | the Chiang-Gui War |
| Date: | May 17–21, 1929 |
| Place: | Guangzhou, Guangdong |
| Result: | Guangdong Army victory |
| Combatant1: | Guangdong Army Supported by: Nationalist government |
| Combatant2: | New Guangxi clique |
| Commander1: | Cai Tingkai |
| Commander2: | Bai Chongxi |
| Strength2: | at least 1 Brigade |
| Casualties2: | 1 Brigade commander captured |
The Second Battle of Guangzhou was fought between the rival armies of the Liangguang region in Southern China as part of the internal conflicts within the Kuomintang leading up to the Central Plains War. The previous month, the New Guangxi clique had fought the Sichuan clique at the Battle of Yichang in Hubei. The forces of the New Guangxi clique attacked Guangzhou from both their home province of Guangxi as well as Jiangxi. Guangdong forces captured a brigade commander of the New Guangxi clique's army.