Secnidazole Explained

Secnidazole (trade names Flagentyl, Sindose, Secnil, Solosec) is a nitroimidazole anti-infective. Effectiveness in the treatment of dientamoebiasis has been reported.^[1] It has also been tested against Atopobium vaginae.^[2]

In the United States, secnidazole is FDA approved for the treatment of bacterial vaginosis and trichomoniasis in adult women.^[3]

Further reading

• Gillis JC, Wiseman LR . Secnidazole. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic use in the management of protozoal infections and bacterial vaginosis . Drugs . 51 . 4 . 621–38 . April 1996 . 8706597 . 10.2165/00003495-199651040-00007 . 195692679 .

Notes and References

1. Girginkardeşler N, Coşkun S, Cüneyt Balcioğlu I, Ertan P, Ok UZ . Dientamoeba fragilis, a neglected cause of diarrhea, successfully treated with secnidazole . Clinical Microbiology and Infection . 9 . 2 . 110–3 . February 2003 . 12588330 . 10.1046/j.1469-0691.2003.00504.x . free .
2. De Backer E, Dubreuil L, Brauman M, Acar J, Vaneechoutte M . In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis . Clinical Microbiology and Infection . 16 . 5 . 470–2 . May 2010 . 19548924 . 10.1111/j.1469-0691.2009.02852.x . free .
3. Muzny CA, Van Gerwen OT . Secnidazole for Trichomoniasis in Women and Men . Sex Med Rev . 10 . 2 . 255–262 . April 2022 . 35153156 . 10.1016/j.sxmr.2021.12.004 . 246755406 . free . 11019772 .