Sec61 alpha 1 explained

Protein transport protein Sec61 subunit alpha isoform 1 is a protein encoded by the SEC61A1 gene in humans.^[1]

The protein encoded by this gene belongs to the SecY/Sec61α family. It plays a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein is found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which contains beta and gamma subunits.^[1]

Further reading

• Wiertz EJ, Tortorella D, Bogyo M, etal . Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. . Nature . 384 . 6608 . 432–8 . 1997 . 8945469 . 10.1038/384432a0 . 6276718 .
• Knight BC . High S . Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex. . Biochem. J. . 331 . 1. 161–7 . 1998 . 9512475 . 1219334 . 10.1042/bj3310161.
• Chen Y . Le Cahérec F . Chuck SL . Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex. . J. Biol. Chem. . 273 . 19 . 11887–94 . 1998 . 9565615 . 10.1074/jbc.273.19.11887. free .
• Bebök Z, Mazzochi C, King SA, etal . The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary. . J. Biol. Chem. . 273 . 45 . 29873–8 . 1998 . 9792704 . 10.1074/jbc.273.45.29873. free .
• Greenfield JJ . High S . The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. . J. Cell Sci. . 112 . 10. 1477–86 . 1999 . 10.1242/jcs.112.10.1477 . 10212142 .
• Yamaguchi A, Hori O, Stern DM, etal . Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. . J. Cell Biol. . 147 . 6 . 1195–204 . 2000 . 10601334 . 2168098 . 10.1083/jcb.147.6.1195.
• Petaja-Repo UE, Hogue M, Laperriere A, etal . Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. . J. Biol. Chem. . 276 . 6 . 4416–23 . 2001 . 11054417 . 10.1074/jbc.M007151200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 139241 . 10.1073/pnas.242603899 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 528928 . 10.1101/gr.2596504 .
• Otsuki T, Ota T, Nishikawa T, etal . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. . DNA Res. . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .

Notes and References

1. Web site: Entrez Gene: SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae).