EXOC2 explained

Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.^{[1] [2] [3]}

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.

Further reading

• Hsu SC, TerBush D, Abraham M, Guo W . The exocyst complex in polarized exocytosis . Int. Rev. Cytol. . 233 . 243–65 . 2004 . 15037366 . 10.1016/S0074-7696(04)33006-8 . International Review of Cytology . 978-0-12-364637-8 .
• Kee Y . Subunit structure of the mammalian exocyst complex . Proc. Natl. Acad. Sci. U.S.A. . 94 . 26 . 14438–43 . 1998 . 9405631 . 10.1073/pnas.94.26.14438 . 25013 . vanc. Yoo JS . Hazuka CD . 3 . Peterson . KE . Hsu . SC . Scheller . RH . free .
• Hsu SC . Subunit composition, protein interactions, and structures of the mammalian brain sec6/8 complex and septin filaments . Neuron . 20 . 6 . 1111–22 . 1998 . 9655500 . 10.1016/S0896-6273(00)80493-6 . vanc. Hazuka CD . Roth R . 3 . Foletti . Davide L. . Heuser . John . Scheller . Richard H. . 10915358 . free.
• Matern HT, Yeaman C, Nelson WJ, Scheller RH . The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells . Proc. Natl. Acad. Sci. U.S.A. . 98 . 17 . 9648–53 . 2001 . 11493706 . 10.1073/pnas.171317898 . 55506 . free .
• Sugihara K . The exocyst complex binds the small GTPase RalA to mediate filopodia formation . Nat. Cell Biol. . 4 . 1 . 73–8 . 2002 . 11744922 . 10.1038/ncb720 . vanc. Asano S . Tanaka K . 3 . Iwamatsu . Akihiro . Okawa . Katsuya . Ohta . Yasutaka . 9528945 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Mott HR . Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site . J. Biol. Chem. . 278 . 19 . 17053–9 . 2003 . 12624092 . 10.1074/jbc.M300155200 . vanc. Nietlispach D . Hopkins LJ . 3 . Mirey . G . Camonis . JH . Owen . D . free.
• Inoue M . The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin . Nature . 422 . 6932 . 629–33 . 2003 . 12687004 . 10.1038/nature01533 . vanc. Chang L . Hwang J . 3 . Chiang . Shian-Huey . Saltiel . Alan R. . 2003Natur.422..629I . 2027.42/62982 . 4395760 . free .
• Fukai S . Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex . EMBO J. . 22 . 13 . 3267–78 . 2003 . 12839989 . 10.1093/emboj/cdg329 . 165653 . vanc. Matern HT . Jagath JR . 3 . Scheller . RH . Brunger . AT .
• Moskalenko S . Ral GTPases regulate exocyst assembly through dual subunit interactions . J. Biol. Chem. . 278 . 51 . 51743–8 . 2004 . 14525976 . 10.1074/jbc.M308702200 . vanc. Tong C . Rosse C . 3 . Mirey . G . Formstecher . E . Daviet . L . Camonis . J . White . MA . free .
• Mungall AJ . The DNA sequence and analysis of human chromosome 6 . Nature . 425 . 6960 . 805–11 . 2003 . 14574404 . 10.1038/nature02055 . vanc. Palmer SA . Sims SK . 3 . Edwards . C. A. . Ashurst . J. L. . Wilming . L. . Jones . M. C. . Horton . R. . Hunt . S. E. . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Beausoleil SA . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . vanc. Jedrychowski M . Schwartz D . 3 . Elias . JE . Villén . J . Li . J . Cohn . MA . Cantley . LC . Gygi . SP . 2004PNAS..10112130B . free .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Jin R . Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase . EMBO J. . 24 . 12 . 2064–74 . 2005 . 15920473 . 10.1038/sj.emboj.7600699 . 1150893 . vanc. Junutula JR . Matern HT . 3 . Ervin . Karen E . Scheller . Richard H . Brunger . Axel T .
• Chien Y . RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival . Cell . 127 . 1 . 157–70 . 2006 . 17018283 . 10.1016/j.cell.2006.08.034 . vanc. Kim S . Bumeister R . 3 . Loo . Yueh-Ming . Kwon . Sung Won . Johnson . Cynthia L. . Balakireva . Mirey G. . Romeo . Yves . Kopelovich . Levy . 9878037 . free .
• Sulem P . Genetic determinants of hair, eye and skin pigmentation in Europeans . Nat. Genet. . 39 . 12 . 1443–52 . 2007 . 17952075 . 10.1038/ng.2007.13 . vanc. Gudbjartsson DF . Stacey SN . 3 . Helgason . Agnar . Rafnar . Thorunn . Magnusson . Kristinn P . Manolescu . Andrei . Karason . Ari . Palsson . Arnar . 19313549 .

Notes and References

1. Murthy M, Garza D, Scheller RH, Schwarz TL . Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists . Neuron . 37 . 3 . 433–47 . Feb 2003 . 12575951 . 10.1016/S0896-6273(03)00031-X . 14351315 . free .
2. Sjolinder M, Uhlmann J, Ponstingl H . DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion . FEBS Lett . 532 . 1–2 . 211–5 . Dec 2002 . 12459492 . 10.1016/S0014-5793(02)03677-3 . 31552100 . free .
3. Web site: Entrez Gene: EXOC2 exocyst complex component 2.