SEC13 explained

Protein SEC13 homolog is a protein that in humans is encoded by the SEC13 gene.^{[1] [2]}

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It has similarity to the yeast SEC13 and SEC31 proteins, which are required for vesicle biogenesis from the endoplasmic reticulum during the transport of proteins.

Further reading

• Shaywitz DA, Orci L, Ravazzola M, etal . Human SEC13Rp functions in yeast and is located on transport vesicles budding from the endoplasmic reticulum. . J. Cell Biol. . 128 . 5 . 769–77 . 1995 . 7876304 . 10.1083/jcb.128.5.769 . 2120388 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Andersson B, Wentland MA, Ricafrente JY, etal . A "double adaptor" method for improved shotgun library construction. . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, etal . Large-scale concatenation cDNA sequencing. . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 10.1101/gr.7.4.353. 139146 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Mammoto A, Sasaki T, Kim Y, Takai Y . Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking. . J. Biol. Chem. . 275 . 18 . 13167–70 . 2000 . 10747849 . 10.1074/jbc.C000096200 . free .
• Tang BL, Zhang T, Low DY, etal . Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport. . J. Biol. Chem. . 275 . 18 . 13597–604 . 2000 . 10788476 . 10.1074/jbc.275.18.13597 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gevaert K, Goethals M, Martens L, etal . Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. . Nat. Biotechnol. . 21 . 5 . 566–9 . 2004 . 12665801 . 10.1038/nbt810 . 23783563 .
• Enninga J, Levay A, Fontoura BM . Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex. . Mol. Cell. Biol. . 23 . 20 . 7271–84 . 2003 . 14517296 . 10.1128/MCB.23.20.7271-7284.2003 . 230331 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Loïodice I, Alves A, Rabut G, etal . The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. . Mol. Biol. Cell . 15 . 7 . 3333–44 . 2005 . 15146057 . 10.1091/mbc.E03-12-0878 . 452587 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Stagg SM, Gürkan C, Fowler DM, etal . Structure of the Sec13/31 COPII coat cage. . Nature . 439 . 7073 . 234–8 . 2006 . 16407955 . 10.1038/nature04339 . 2006Natur.439..234S . 2426465 .

Notes and References

1. Swaroop A, Yang-Feng TL, Liu W, Gieser L, Barrow LL, Chen KC, Agarwal N, Meisler MH, Smith DI . Molecular characterization of a novel human gene, SEC13R, related to the yeast secretory pathway gene SEC13, and mapping to a conserved linkage group on human chromosome 3p24-p25 and mouse chromosome 6 . Hum Mol Genet . 3 . 8 . 1281–6 . Jan 1995 . 7987303 . 10.1093/hmg/3.8.1281 .
2. Web site: Entrez Gene: SEC13 SEC13 homolog (S. cerevisiae).