| Sebhat Ephrem | |
| Order: | Minister of Energy and Mines |
| Term Start: | 2013 |
| President: | Isaias Afwerki |
| Order1: | 3rd Minister of Defence |
| Term Start1: | 1995 |
| Term End1: | 2013 |
| Predecessor1: | Mesfin Hagos |
| Successor1: | Filipos Woldeyohannes |
| Order2: | 2nd Minister of Health |
| Term Start2: | 1994 |
| Term End2: | 1995 |
| Predecessor2: | Haile Mehtsun |
| Successor2: | Saleh Meki |
| Birth Place: | Asmara, Eritrea[1] |
| Party: | PFDJ |
| Battles: | |
| Allegiance: | EPLF Eritrea |
Sebhat Ephrem is an Eritrean military officer and politician who is the Minister of Energy and Mines for Eritrea. He was also the former Minister of Defence and former Eritrean People's Liberation Front (EPLF) commander during the Eritrean War of Independence.
Sebhat Ephrem was born in Asmara, Eritrea. His father was a Protestant-educated hospital administrator. He studied pharmacy at Addis Ababa University for two years before joining the EPLF in 1972.
He quickly rose up the ranks from a political commissar to becoming part of the executive committee in 1977. He became the General Staff of the EPLA in 1986 and was credited as the leading strategist of the victories at Afabet, Massawa and Dekemhare. After liberation Sebhat Ephrem served from June 1992 to March 1994 as the Governor of Asmara. From March 1994 to May 1995 he served as the Minister of Health. In both positions he brought structure and reorganization to these offices. After leaving the military in June 1992, he returned to the army in May 1995 with the rank of general and was appointed and confirmed as Minister of Defense. It is believed that in 1998 he was the only 4-star general in the Eritrean Defence forces.