| Sebastian Skube | |
| Nationality: | Slovenian |
| Birth Date: | 3 April 1987 |
| Birth Place: | Novo Mesto, SFR Yugoslavia |
| Position: | Centre back |
| Currentclub: | Chambéry SMBH |
| Clubnumber: | 11 |
| Years1: | 2005–2010 |
| Clubs1: | RK Trimo Trebnje |
| Years2: | 2010–2012 |
| Clubs2: | RK Koper |
| Years3: | 2012–2014 |
| Clubs3: | RK Celje |
| Years4: | 2014–2021 |
| Clubs4: | Bjerringbro-Silkeborg |
| Years5: | 2021– |
| Clubs5: | Chambéry SMBH |
| Nationalyears1: | 2007–2016 |
| Nationalteam1: | Slovenia[1] |
| Nationalcaps1: | 129 |
| Nationalgoals1: | 281 |
Sebastian Skube (born 3 April 1987) is a Slovenian professional handball player who plays for Chambéry SMBH. He represented Slovenia at the 2013 World Men's Handball Championship. He is the older brother of Staš Skube.