| Sebastião Lopes de Calheiros e Meneses | |
| Birth Date: | 24 January 1816 |
| Birth Place: | Geraz do Lima, Viana do Castelo |
| Death Date: | 20 November 1899 |
| Nationality: | Portuguese |
| Office: | Colonial governor of Cape Verde |
| Term Start: | 28 March 1858 |
| Term End: | June 1860 |
| Predecessor: | António Maria Barreiros Arrobas |
| Successor: | Januário Correia de Almeidà |
| Office2: | Colonial governor of Angola |
| Term Start2: | February 1861 |
| Term End2: | September 1862 |
| Predecessor2: | Carlos Augusto Franco |
| Successor2: | José Baptista de Andrade |
Sebastião Lopes de Calheiros e Meneses (24 January 1816 – 20 November 1899) was a Portuguese colonial administrator. He was the governor of Cape Verde and of Angola. He was born on 24 January 1816 in Geraz do Lima, northern Portugal. His father was Pedro Lopes de Calheiros e Meneses.[1] He succeeded António Maria Barreiros Arrobas as governor of Cape Verde on 28 March 1858, and was succeeded by Januário Correia de Almeida in June 1860.[2] He succeeded Carlos Augusto Franco as governor of Angola in February 1861, and was succeeded by José Baptista de Andrade in September 1862.[3] He was Minister of Public Works in the government of Sá da Bandeira (1868-1869).[4] He died in Viana do Castelo on 20 November 1899.[1]