| Sebastián Calderón Centeno | |
| Office: | Senator for Campeche |
| Term Start: | 1 September 2006 |
| Term End: | 31 August 2012 |
| Predecessor: | Jorge Nordhausen |
| Successor: | Jorge Luis Lavalle Maury |
| Birth Date: | 1946 1, df=yes |
| Birth Place: | Ciudad del Carmen, Campeche, Mexico |
| Occupation: | Senator |
Sebastián Calderón Centeno (born 20 January 1946) is a Mexican politician affiliated with the National Action Party (PAN). In 2006–2012 he served as a senator in the 60th and 61st sessions of Congress, representing Campeche. He also served as a federal deputy in the 59th Congress (2003–2006), representing Campeche's 2nd district.[1]