| Satyaprajna Tirtha | |
| Honorific Prefix: | His Holiness Śri Śri 1008 |
| Honorific Suffix: | Sripad |
| Religion: | Hinduism |
| Birth Name: | Pandurangi Jayacharya |
| Birth Place: | North Karnataka |
| Death Date: | 14 April 1945 |
| Death Place: | Athakuru |
| Honors: | Shri |
| Order: | Vedanta (Uttaradi Math) |
| Guru: | Satyadhyana Tirtha |
| Successor: | Satyabhijna Tirtha |
| Philosophy: | Dvaita Vedanta |
Satyaprajna Tirtha was an Indian philosopher, Hindu spiritual leader, guru, saint and the pontiff of Uttaradi Math, a matha (mutt) dedicated to the Dvaita philosophy, which has a large following in southern India. He was the 39th pontiff of Uttaradi Math since Madhvacharya, reformer of the Dvaita philosophy from 24 March 1942 to 14 April 1945.