| Saturn Award for Best Supporting Actress | |
| Awarded For: | Best performance of the year by a female in a supporting role in a genre film |
| Presenter: | Academy of Science Fiction, Fantasy and Horror Films |
| Country: | United States |
| Year: | 1974/75 |
| Holder: | Emily Blunt for Oppenheimer (2022/2023) |
The following is a list of Saturn Award nominees and winners for Best Supporting Actress, which rewards the best female supporting performance in a genre film. Anne Ramsey, Tilda Swinton, and Emily Blunt are the only actresses to win this award multiple times (twice), while only Whoopi Goldberg and Mercedes Ruehl have won both the Saturn Award and the Academy Award for Best Supporting Actress for the same role.
| Year | Actress | Motion Picture | Character |
|---|---|---|---|
| Ida Lupino | The Devil's Rain | Mrs. Preston | |
| Bette Davis | Burnt Offerings | Aunt Elizabeth | |
| Susan Tyrrell | Bad | Mary Aiken | |
| Joan Bennett | Suspiria | Madame Blanc | |
| Teri Garr | Close Encounters of the Third Kind | Ronnie Neary | |
| Alexis Smith | The Little Girl Who Lives Down the Lane | Mrs. Hallet | |
| Margaret Whiting | Sinbad and the Eye of the Tiger | Zenobia | |
| Dyan Cannon | Heaven Can Wait | Julia Farnsworth | |
| Uta Hagen | The Boys from Brazil | Frieda Maloney | |
| Mabel King | The Wiz | Evillene | |
| Valerie Perrine | Superman | Eve Teschmacher | |
| Brenda Vaccaro | Capricorn One | Kay Brubaker | |
| Veronica Cartwright | Alien | Lambert | |
| Pamela Hensley | Buck Rogers in the 25th Century | Princess Ardala | |
| Jacquelyn Hyde | The Dark | De Renzy | |
| Marcy Lafferty | The Day Time Ended | Beth | |
| Nichelle Nichols | Lt. Cmdr. Uhura |
| Year | Actress | Motion Picture | Character |
|---|---|---|---|
| Awkwafina | Shang-Chi and the Legend of the Ten Rings | Katy Chen | |
| Carrie Coon | Callie Spengler | ||
| Jodie Comer | Free Guy | Millie Rusk | |
| Viola Davis | The Suicide Squad | Amanda Waller | |
| Stephanie Hsu | Everything Everywhere All at Once | Joy Wang / Jobu Tupaki | |
| Diana Rigg (posthumously) | Last Night in Soho | Mrs. Collins | |
| Marisa Tomei | May Parker | ||
| Emily Blunt | Oppenheimer | Katherine 'Kitty' Oppenheimer | |
| Angela Bassett | Queen Ramonda | ||
| Jane Curtin | Jules | Joyce | |
| Melissa McCarthy | The Little Mermaid | Ursula | |
| Phoebe Waller-Bridge | Indiana Jones and the Dial of Destiny | Helena Shaw | |
| Sophie Wilde | Talk to Me | Mia |