Saswati Chatterjee Explained

Fields:Virology
Workplaces:City of Hope
Education:McGill University; Cell, Molecular Biology & Immunology
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Known For:Research of AAV-vectors in Gene Expression
Awards:Fogarty NIH Visiting Fellowship, Mayo Foundation Fellowship, Medical Research Council Post Doctoral Fellowship, McGill University Faculty of Medicine Graduate Student Award, Arthur W. Ham Graduate Student Award - Canadian Federation of Biological Societies, J.W. McConnell Scholarship in Science & Engineering
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Saswati Chatterjee is a virologist working as a professor at the Los Angeles City of Hope National Medical Center in the research department. Some of the viral areas she researches are: stem cells, gene therapy, genome editing, and parvovirus. Her main and current area of research is using Adeno-Associated Virus Vectors (AAV-Vectors). Additionally, she has had a role in many publications (see publications).

Education and training

Chatterjee received her B.Sc. in Cell & Molecular Biology from McGill University in Montreal, Canada. She continued on at McGill and received her Ph.D. in Immunology.[1]

Research contributions

Adeno-Associated Virus vectors can be used for stem cell gene therapy.[2] Adenovirus' have a Baltimore classification of level I, meaning that they have a liner dsDNA genome within an icosahedral nucleocapsid. Some of their advantages as vectors are that they are considered to be efficient at gene delivery and can infect nondividing cells.[3] Other disadvantages are that adeno-associated viruses are immunogenic, high toxicity and have a small packaging limit.

One of Chatterjee's most notable publications is from 1999, and she researched the use of a "single stranded AAV, replication-defective nonpathogenic human parvovirus with a 4.7kb DNA genome with a palindromic inverted terminal repeats" [4] This process REQUIRES the use of an adenovirus for the DNA to enter the cell and cause infection, thus being stably integrated into the cells DNA genome in a specific place. This study showed that the AAV vector was successful at efficiently transferring DNA into nondividing cells. Another publication that Chatterjee researched and featured in, regarded the effective transduction of CD34+ cells. They found that AAV transduction gave way to altered viral chromosomal integration.[5]

Awards and honors

Publications

Chatterjee has made contributions in 38 publications, on many of which she has been the lead researcher and author. Some of her best known publications are listed here.

Notes and References

  1. Web site: Saswati Chatterjee. City of Hope. 11 May 2015.
  2. Web site: SASWATI CHATTERJEE, PH.D. RESEARCH. City of Hope. 11 May 2015.
  3. Book: Flint. S.J.. Racaniello. V.A.. Enquist. L.W.. Skalka. A.M.. Principles of virology.. 2009. ASM. Washington, D.C.. 9781555814793. 3rd ed., rev..
  4. Chatterjee. S. Li. W. Wong. CA. Fisher-Adams. G. Lu. D. Guha. M. Macer. JA. Forman. SJ. Wong KK. Jr. Transduction of primitive human marrow and cord blood-derived hematopoietic progenitor cells with adeno-associated virus vectors.. Blood. 15 March 1999. 93. 6. 1882–94. 10.1182/blood.V93.6.1882.406k03_1882_1894. 10068661.
  5. Fisher-Adams. Grace. Wong Jr. K.K.. Podsakoff. Greg. Forman. Stephen J.. Chatterjee. Saswatti. INtegration of Adenoassociated Virus Vectors in CD34+ HUman Hemotopoietic Progenitor Cells After Transduction. Blood. July 15, 1996. 88. 2. 492–504. 10.1182/blood.V88.2.492.bloodjournal882492. 8695797. free.

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