| Province: | SK |
| Type: | Hwy |
| Route: | 45 |
| Photo Notes: | Highway 45 near Macrorie |
| Photo Width: | 250 |
| Length Km: | 115.5 |
| Length Round: | 1 |
| Direction A: | South |
| Terminus A: | at Lucky Lake |
| Junction: | at Macrorie near Outlook |
| Direction B: | North |
| Terminus B: | near Delisle |
| Rural Municipalities: | Canaan, Coteau, Fertile Valley, Montrose, Vanscoy |
| Previous Type: | Hwy |
| Previous Route: | 44 |
| Next Type: | Hwy |
| Next Route: | 46 |
Highway 45 is a provincial highway in the Canadian province of Saskatchewan. It runs from Highway 42 at Lucky Lake to Highway 7 near Delisle. The highway is about long.
Highway 45 passes near the communities of Lucky Lake, Tullis, Birsay, Lyons, Macrorie, Swanson, Donavon, and Delisle.
From south to north:[1]