| Province: | SK |
| Type: | Hwy |
| Route: | 381 |
| Photo Width: | 250 |
| Length Km: | 24.5 |
| Length Round: | 1 |
| Direction A: | West |
| Terminus A: | north of Churchbridge |
| Junction: | at MacNutt |
| Direction B: | East |
| Terminus B: | at Manitoba border near MacNutt |
| Rural Municipalities: | Churchbridge |
| Previous Type: | Hwy |
| Previous Route: | 379 |
| Next Type: | Hwy |
| Next Route: | 394 |
Highway 381 is a provincial highway in the Canadian province of Saskatchewan. It runs from Highway 80 until the Manitoba border, where it transitions into Provincial Road 547. It is about long.
Highway 381 passes near the town of MacNutt and intersects Highway 8.