| Province: | SK |
| Type: | Hwy |
| Route: | 321 |
| Photo Width: | 250 |
| Length Km: | 33.0 |
| Length Round: | 1 |
| Direction A: | West |
| Terminus A: | at Alberta border near Burstall |
| Direction B: | East |
| Terminus B: | near Liebenthal |
| Rural Municipalities: | Enterprise, Fox Valley |
| Towns: | Burstall |
| Previous Type: | Hwy |
| Previous Route: | 320 |
| Next Type: | Hwy |
| Next Route: | 322 |
Highway 321 is a provincial highway in the Canadian province of Saskatchewan. It runs from Highway 21 near Liebenthal to the Alberta border, where it becomes Highway 545. The highway also connects with Highway 635 and passes near the town of Burstall near the Alberta border. It is about long.