Sarolaner Explained

Tradename:Simparica
Atcvet:Yes
Atc Prefix:P53
Atc Suffix:BE03
Legal Ca:Rx-only
Legal Ca Comment:[1] [2] [3]
Legal Us:Rx-only
Legal Us Comment:[4]
Legal Eu:Rx-only
Legal Eu Comment:[5] [6]
Cas Number:1398609-39-6
Chembl:3137302
Pubchem:73169092
Chemspiderid:31458198
Kegg:D10668
Unii:DM113FTW7F
Synonyms:PF-6450567
Iupac Name:1-[6-[(5''S'')-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4''H''-1,2-oxazol-3-yl]spiro[1''H''-2-benzofuran-3,3'-azetidine]-1'-yl]-2-methylsulfonylethanone
C:23
H:18
Cl:2
F:4
N:2
O:5
S:1
Stdinchi:1S/C23H18Cl2F4N2O5S/c1-37(33,34)9-19(32)31-10-21(11-31)15-3-2-12(4-13(15)8-35-21)18-7-22(36-30-18,23(27,28)29)14-5-16(24)20(26)17(25)6-14/h2-6H,7-11H2,1H3/t22-/m0/s1
Stdinchikey:FLEFKKUZMDEUIP-QFIPXVFZSA-N
Smiles:CS(=O)(=O)CC(=O)N1CC2(C1)OCc1cc(C3=NO[C@@](c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)ccc12

Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs.[7] [8] It is also used off-label to control sarcoptic mange and demodectic mange.[8]

Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel.[9] [10] It is used for prevention of heartworm disease caused by Dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the lone star tick, Gulf Coast tick, American dog tick, black-legged tick, and brown dog tick; and treat and control roundworm and adult hookworm infections.[11]

Sarolaner is also an ingredient in feline combination antiparasitic Revolution Plus (or Stronghold Plus[12]), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline roundworms, ear mites, and heartworms, as well as treating and preventing fleas and ticks.[13]

Notes and References

  1. Web site: Notice: Prescription Drug List (PDL): Multiple additions [2016-08-09] ]. . 9 August 2016 . 10 July 2024.
  2. Web site: Drug and medical device highlights 2018: Helping you maintain and improve your health . . 14 October 2020 . 10 July 2024 . 17 April 2024 . https://web.archive.org/web/20240417063539/https://www.canada.ca/en/health-canada/services/publications/drugs-health-products/drug-medical-device-highlights-2018.html . live .
  3. Web site: Drug and medical device highlights 2019: Helping you maintain and improve your health . . 18 November 2020 . 10 July 2024.
  4. Web site: Simparica . U.S. Food and Drug Administration (FDA) . 12 December 2022 . 10 July 2024 . https://web.archive.org/web/20240710045416/https://animaldrugsatfda.fda.gov/adafda/views/#/search#/home/previewsearch/141-452 . live .
  5. Web site: Simparica EPAR . European Medicines Agency . 18 December 2015 . 13 June 2024 . 10 July 2024 . https://web.archive.org/web/20240710045417/https://www.ema.europa.eu/en/medicines/veterinary/EPAR/simparica . live .
  6. Web site: MiPet Easecto EPAR . European Medicines Agency . 23 February 2018 . 13 June 2024 . 10 July 2024 . https://web.archive.org/web/20240710045416/https://www.ema.europa.eu/en/medicines/veterinary/EPAR/mipet-easecto . live .
  7. McTier TL, Chubb N, Curtis MP, Hedges L, Inskeep GA, Knauer CS, Menon S, Mills B, Pullins A, Zinser E, Woods DJ, Meeus P . Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs . Veterinary Parasitology . 222 . 3–11 . May 2016 . 26961590 . 10.1016/j.vetpar.2016.02.019 . 13 March 2022 . 4 November 2020 . https://web.archive.org/web/20201104181606/https://discovery.dundee.ac.uk/ws/files/49833501/1_s2.0_S0304401716300425_main.pdf . live .
  8. Web site: Sarolaner . Gollakner R . vcahospitals.com . VCA Hospitals . 26 June 2021 . 27 June 2021 . https://web.archive.org/web/20210627143214/https://vcahospitals.com/know-your-pet/sarolaner . live .
  9. Web site: Simparica Trio . U.S. Food and Drug Administration (FDA) . 12 December 2022 . 9 December 2022 . https://web.archive.org/web/20221209203715/https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141-521 . live .
  10. Web site: Simparica Trio EPAR . European Medicines Agency . 14 October 2019 . 15 June 2024 . 15 June 2024 . https://web.archive.org/web/20240615220605/https://www.ema.europa.eu/en/medicines/veterinary/EPAR/simparica-trio . live .
  11. Web site: FDA Approves Simparica Trio, a Combination Drug for Heartworm and Other Parasites . U.S. Food and Drug Administration (FDA) . 2 March 2020 . 26 June 2021 . 24 September 2021 . https://web.archive.org/web/20210924194212/https://www.fda.gov/animal-veterinary/cvm-updates/fda-approves-simparica-trio-combination-drug-heartworm-and-other-parasites . live .
  12. Web site: Stronghold Plus . European Medicines Agency . 9 March 2017 . 12 December 2022 . 10 July 2024 . https://web.archive.org/web/20240710045417/https://www.ema.europa.eu/en/medicines/veterinary/EPAR/stronghold-plus . live .
  13. Web site: Revolution Plus . U.S. Food and Drug Administration (FDA) . 12 December 2022 . 10 July 2024 . https://web.archive.org/web/20240710045416/https://animaldrugsatfda.fda.gov/adafda/views/#/search#/home/previewsearch/141-502 . live .

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