Sarcalumenin Explained

Sarcalumenin is a protein that in humans is encoded by the SRL gene.^{[1] [2]}

Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle.^[3] Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins.^[4] Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity.^[3] Sarcalumenin is a calcium-binding glycoprotein composed of 473 acidic amino acids with a molecular weight of 160 KDa. Together along with other luminal calcium buffer proteins, sarcalumenin plays an important role in regulation of calcium uptake and release during excitation-contraction coupling (ECC) in muscle fibers.

Notes and References

1. Leberer E, Charuk JH, Green NM, MacLennan DH . Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum . Proceedings of the National Academy of Sciences of the United States of America . 86 . 16 . 6047–51 . August 1989 . 2762314 . 297772 . 10.1073/pnas.86.16.6047 . 1989PNAS...86.6047L . free .
2. Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, Toppo S, Trevisan S, Scarso S, Valle G . Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization . Genome Research . 6 . 1 . 35–42 . January 1996 . 8681137 . 10.1101/gr.6.1.35 . free .
3. Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, Minamisawa S . Sarcalumenin is essential for maintaining cardiac function during endurance exercise training . American Journal of Physiology. Heart and Circulatory Physiology . 297 . 2 . H576-82 . August 2009 . 19502553 . 2724216 . 10.1152/ajpheart.00946.2008 .
4. Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, Takeshima H . Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice . The Journal of Biological Chemistry . 280 . 5 . 3500–6 . February 2005 . 15569689 . 10.1074/jbc.M406618200 . free .