Sarah Teichmann Explained

Sarah Teichmann
Birth Name:Sarah Amalia Teichmann
Birth Date:15 April 1975
Birth Place:Karlsruhe, West Germany
(now Germany)
Education:European School, Karlsruhe
Alma Mater:University of Cambridge (BA, MA, PhD)
Thesis Title:Genome evolution: analysing proteomes with new methods
Thesis Url:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624585
Thesis Year:1999
Doctoral Advisor:Cyrus Chothia[1] [2]
Doctoral Students:M. Madan Babu[3]
Children:2[4] [5]

Sarah Amalia Teichmann (born 15 April 1975)[6] [7] is a German scientist who is head of cellular genetics at the Wellcome Sanger Institute[8] and a visiting research group leader at the European Bioinformatics Institute (EMBL-EBI).[9] [1] She serves as director of research (equivalent to Professor)[10] in the Cavendish Laboratory,[11] at the University of Cambridge and a senior research fellow at Churchill College, Cambridge.[12] [13]

Education

Teichmann was educated at the European School, Karlsruhe in Germany from 1981 to 1993 where she completed the European Baccalaureate in 1993.[14] Teichmann went on to study the Natural Sciences Tripos at Trinity College, Cambridge and was awarded a first class Bachelor of Arts degree in 1996. In 1999, she completed her PhD supervised by Cyrus Chothia[15] at the Laboratory of Molecular Biology (LMB) on genome evolution.[16]

Career and research

Following her PhD, Teichmann did postdoctoral research supervised by Janet Thornton at University College London[9] and funded by the Beit Memorial Fellowships for Medical Research. From 2001-2012, she was a Medical Research Council (MRC) Programme Leader, studying patterns in protein interactions and transcriptional regulatory networks.[17] [18]

In 2013 Teichmann was appointed a joint position at the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EMBL-EBI). From 2005 to 2015 she served as a teaching fellow and director of studies at Trinity College, Cambridge. Since 2016 Teichmann has served as the head of Cellular Genetics at the Wellcome Trust Sanger Institute and a visiting research group leader at the EBI.[1]

Teichmann's research investigates gene expression[19] [20] [21] and protein complex assembly[22] using both wet laboratory and computational biology techniques.[23] In particular her research group:

Teichmann's research has been funded by the European Research Council (ERC), the Medical Research Council (MRC), the Biotechnology and Biological Sciences Research Council (BBSRC),[24] the Wellcome Trust, the European Molecular Biology Organization (EMBO), the Framework Programmes for Research and Technological Development and the European Cooperation in Science and Technology (COST).[14]

Teichmann has supervised several PhD students to completion[25] [14] including Madan Babu,[3] Varodom Charoensawan[26] Subhajyoti De[27] Jay Han,[28] Sarah Kay Kummerfeld[29] [30] Tina Perica,[31] and Jing Su,[32] and several postdoctoral researchers who have gone on to become Principal investigators (PIs).[14] [33] [34] [35]

Awards and honours

Teichmann has won a number of awards. In 2010, she was awarded the Colworth Medal from the Biochemical Society.[36] In 2012, Teichman was awarded the Francis Crick Medal and Lecture, membership of the European Molecular Biology Organization (EMBO) and the Lister Prize from the Lister Institute of Preventive Medicine. In 2015 she was awarded the Michael and Kate Bárány Award for young investigators by the Biophysical Society[37] and the EMBO Gold Medal. Teichmann was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2015. Her citation on election reads: Teichmann has also been an activist for women's careers in science through enabling scientists in families to advance their careers while working part-time.[38] She chaired a Sex in Science debate at the Wellcome Trust on balancing family life with working in research. Teichmann was elected an ISCB Fellow in 2016 by the International Society for Computational Biology.[39]

In 2020, Teichmann was recognised on The Times 'Science Power List' for her work on the Human Cell Atlas[40] and elected a Fellow of the Royal Society.[41] She won the Suffrage Science award in 2012.[42]

In 2023 Teichmann was the winner of the Federation of European Biochemical Societies (FEBS) EMBO Women in Science Award.[43]

Personal life

Teichmann has two daughters.[4] [44] Teichmann is the co-author of the children's language education novel Teenage Detectives,[45] which she wrote as a teenager together with her mother Dr. Virginia Teichmann, an English-language university lecturer in Karlsruhe.[46]

Notes and References

  1. Web site: People & Groups: Sarah Teichmann, Group Leader - Teichmann research group. https://web.archive.org/web/20130403001859/http://www.ebi.ac.uk/about/people/sarah-teichmann. EMBL-EBI. 2013. 2013-04-03.
  2. 9367767. 1997. Park. J. Intermediate sequences increase the detection of homology between sequences. Journal of Molecular Biology. 273. 1. 349–54. Teichmann. S. A.. Sarah Teichmann. Hubbard. T. Tim Hubbard. Chothia. C. Cyrus Chothia. 10.1006/jmbi.1997.1288. 28606158.
  3. PhD. University of Cambridge. Evolution of transcriptional regulatory networks. Madan Babu. Mohan. 2004. . jisc.ac.uk. 890159758.
  4. Web site: Sarah Teichmann: 'I wake as early as 4am and think about work'. The Guardian. London. Rosanna . Greenstreet. 2018.
  5. 10.1038/nmeth.2831. 24645189. The Author File: Janet Thornton. Nature Methods. 11. 2. 115. 2014. Marx . Vivien . 1970327. free.
  6. Web site: Teichmann. Sarah. Sarah Amalia Teichmann PhD MA BA (Hons cantab) CV . mrc-lmb.cam.ac.uk . 2007 . Laboratory of Molecular Biology . 2013-02-26. https://web.archive.org/web/20130226050525/http://www.mrc-lmb.cam.ac.uk/genomes/Sarah/bio_teich07.pdf.
  7. Web site: Anon. 2015. https://web.archive.org/web/20150706123113/http://www.acmedsci.ac.uk/fellows/fellows-directory/ordinary-fellows/dr-sarah-teichmann/. 2015-07-06. acmedsci.ac.uk. Dr Sarah Teichmann FMedSci. Academy of Medical Sciences. London.
  8. Web site: https://web.archive.org/web/20160415075045/http://www.sanger.ac.uk/people/directory/teichmann-sarah. 2016-04-15. Dr Sarah Teichmann, FMedSci, Head of Cellular Genetics. sanger.ac.uk. Cambridge.
  9. Marx. Vivien. The Author File: Sarah Teichmann. Nature Methods. 13. 4. 2016. 279. 1548-7091. 10.1038/nmeth.3808. 27203785. 205424792. free.
  10. Web site: https://web.archive.org/web/20130703200917/http://www.cam.ac.uk/research-staff/employment-and-career-management/employment-and-career-management-scheme/researchers-employment-policies-and-protocols/job-titles-and-duties. Job titles and duties at the University of Cambridge. Anon. 2013. 2013-07-03. University of Cambridge.
  11. Web site: https://web.archive.org/web/20150912194932/http://www.tcm.phy.cam.ac.uk/profiles/sat1003/. 2015-09-12. Dr Sarah Teichmann FMedSci. tcm.phy.cam.ac.uk. Cambridge. Anon. 2015.
  12. Web site: People – Churchill College. www.chu.cam.ac.uk.
  13. Dhillon. Paraminder. Teichmann. Sarah A.. In conversation with Sarah Teichmann. The FEBS Journal. 286. 8. 2019. 1445–1450. 1742-464X. 10.1111/febs.14806. 31012289. free.
  14. Web site: Sarah Teichmann: 40th FEBS Congress - The Biochemical Basis of Life - Berlin, Germany . Federation of European Biochemical Societies . 2015. 2015-02-20. Anon. https://web.archive.org/web/20150220171117/http://www.febs2015.org/Sarah-Teichmann.996.0.html.
  15. 12805536. 2003. Chothia. C. Cyrus Chothia. Evolution of the protein repertoire. Science. 300. 5626. 1701–3. Gough. J. Julian Gough (scientist). Vogel. C. Teichmann. S. A.. Sarah Teichmann. 10.1126/science.1085371. 2003Sci...300.1701C. 27681885.
  16. PhD . Sarah Amalia. Teichmann . Genome evolution : analysing proteomes with new methods. University of Cambridge . 1999 . 894602472. .
  17. 15193307. 2004. Babu. M. M.. Structure and evolution of transcriptional regulatory networks. Current Opinion in Structural Biology. 14. 3. 283–91. Luscombe. N. M.. Aravind. L. Gerstein. M. Mark Bender Gerstein. Teichmann. S. A.. Sarah Teichmann. 10.1016/j.sbi.2004.05.004. 10.1.1.471.9692.
  18. 15372033. 2004. Luscombe. N. M.. Genomic analysis of regulatory network dynamics reveals large topological changes. Nature. 431. 7006. 308–12. Babu. M. M.. Yu. H. Snyder. M. Teichmann. S. A.. Sarah Teichmann. Gerstein. M. Mark Bender Gerstein. 10.1038/nature02782. 2004Natur.431..308L. 4391278.
  19. 16141072. 2005. Carninci. P. The transcriptional landscape of the mammalian genome. Science. 309. 5740. 1559–63. Kasukawa. T. Katayama. S. Gough. J. Julian Gough (scientist). Frith. M. C.. Maeda. N. Oyama. R. Ravasi. T. Lenhard. B. Wells. C. Kodzius. R. Shimokawa. K. Bajic. V. B.. Brenner . S. E. . Steven E. Brenner. Batalov. S. Forrest. A. R.. Zavolan. M. Davis. M. J.. Wilming. L. G.. Aidinis. V. Allen. J. E.. Ambesi-Impiombato. A. Apweiler. R. Rolf Apweiler. Aturaliya. R. N.. Bailey. T. L.. Bansal. M. Baxter. L. Beisel. K. W.. Bersano. T. Bono. H. 29. 10.1126/science.1112014. 2005Sci...309.1559F. 8712839.
  20. 17994087. 2007. Drosophila 12 Genomes. Consortium. Evolution of genes and genomes on the Drosophila phylogeny. Nature. 450. 7167. 203–18. Clark. A. G.. Eisen. M. B.. Michael Eisen. Smith. D. R.. Bergman. C. M.. Oliver. B. Markow. T. A.. Kaufman. T. C.. Kellis. M. Gelbart. W. Iyer. V. N.. Pollard. D. A.. Sackton. T. B.. Larracuente. A. M.. Singh. N. D.. Abad. J. P.. Abt. D. N.. Adryan. B. Aguade. M. Akashi. H. Anderson. W. W.. Aquadro. C. F.. Ardell. D. H.. Arguello. R. Artieri. C. G.. Barbash. D. A.. Barker. D. Barsanti. P. Batterham. P. Batzoglou. S. 29. 10.1038/nature06341. 2007Natur.450..203C. free.
  21. 18073188. 2238844. 2008. Wilson. D. DBD--taxonomically broad transcription factor predictions: New content and functionality. Nucleic Acids Research. 36. Database issue. D88–92. Charoensawan. V. Kummerfeld. S. K.. Teichmann. S. A.. 10.1093/nar/gkm964.
  22. Book: 23663964. 2013. Levy. E. D.. Oligomerization in Health and Disease. 117. 25–51. Teichmann. S. 10.1016/B978-0-12-386931-9.00002-7. Structural, Evolutionary, and Assembly Principles of Protein Oligomerization. Progress in Molecular Biology and Translational Science. 9780123869319.
  23. 25525255. 4337988. 2014. Perica. T. Evolution of oligomeric state through allosteric pathways that mimic ligand binding. Science. 346. 6216. 1254346. Kondo. Y. Tiwari. S. P.. McLaughlin. S. H.. Kemplen. K. R.. Zhang. X. Steward. A. Reuter. N. Clarke. J. Jane Clarke (scientist). Teichmann. S. A. . Sarah Teichmann. 10.1126/science.1254346.
  24. Web site: UK Government research grants awarded to Sarah Teichmann. Anon. Research Councils UK. https://web.archive.org/web/20150303105747/http://gtr.rcuk.ac.uk/person/E7D7D43E-7A50-4275-A7D7-CBCA7E9D5E16. 2015. 2015-03-03.
  25. Web site: Alumni from Sarah Teichmann's Group . Teichmann . Sarah . 2015 . European Bioinformatics Institute . 2024-05-27 . https://archive.today/20240527054958/https://www.webcitation.org/6WUCOq6D4?url=https://www.ebi.ac.uk/~saraht/people.html . dead .
  26. PhD . Varodom. Charoensawan . Evolution and dynamics of transcription factors and gene expression patterns . University of Cambridge . 2011 . 890150091. ethos.bl.uk.
  27. PhD . Subhajyoti. De . Human genome evolution : investigating protein divergence, polymorphisms and genomic neighbourhood . University of Cambridge . 2008. 890154864 . ethos.bl.uk.
  28. PhD . Jay. Han . Structure, function and evolution of protein-protein interactions. University of Cambridge . 2007 .
  29. PhD . Sarah Kay. Kummerfeld . Towards understanding the protein universe : genome-scale studies of evolution and gene regulation. University of Cambridge . 2006. ethos.bl.uk.
  30. PhD. Emmanuel Doram. Levy. Classification, evolution, and assembly of protein complexes. University of Cambridge. 2008. ethos.bl.uk.
  31. PhD. Tina. Perica. Evolutionary and structural dynamics of protein complexes . University of Cambridge. 2013. 890148231.
  32. PhD. Jing. Su. Computational prediction of regulatory elements. University of Cambridge. 2012.
  33. 20384991. 2884543. 2010. Adryan. B. The developmental expression dynamics of Drosophila melanogaster transcription factors. Genome Biology. 11. 4. R40. Teichmann. S. A.. 10.1186/gb-2010-11-4-r40. free.
  34. 19039133. 2008. Gsponer. J. Tight regulation of unstructured proteins: From transcript synthesis to protein degradation. Science. 322. 5906. 1365–8. Futschik. M. E.. Teichmann. S. A.. Babu. M. M.. 10.1126/science.1163581. 2803065. 2008Sci...322.1365G.
  35. 21131282. 3061070. 2011. Hebenstreit. D. EpiChIP: Gene-by-gene quantification of epigenetic modification levels. Nucleic Acids Research. 39. 5. e27. Gu. M. Haider. S. Turner. D. J.. Liò. P. Teichmann. S. A.. 10.1093/nar/gkq1226.
  36. Web site: Women at Cambridge: Sarah Amalia Teichmann. Anon. 2015. University of Cambridge. https://web.archive.org/web/20150220162433/http://www.cam.ac.uk/women-at-cambridge/profiles/sarah-a-teichmann. 2015-02-20.
  37. Web site: Biophysical Society Names 2015 Award Recipients. Biophysical Society. 8 March 2015. 4 October 2014. https://web.archive.org/web/20141004183808/http://www.biophysics.org/Portals/1/PDFs/Press%20Room/2014/2015%20Award%20Recipients%20press%20release.pdf. dead.
  38. Web site: Gaskell & Kostic. The Unstoppable Sarah Teichmann on Programing, Motherhood, and Protein Complex Assembly:The Female Scientist. Cell. 2015. 2015-11-25. https://web.archive.org/web/20160402112200/http://crosstalk.cell.com/blog/sarah-teichmann-on-programming-motherhood-and-complex-assembly. 2016-04-02. dead.
  39. Web site: https://web.archive.org/web/20170320114530/https://www.iscb.org/iscb-fellows. 2017-03-20. ISCB Fellows. iscb.org. International Society for Computational Biology. Anon. 2017.
  40. News: Franklin-Wallis. Oliver. 23 May 2020. From pandemics to cancer: the science power list. en. The Times. 2020-05-26. 0140-0460.
  41. Web site: Sarah Teichmann. Royal Society. 20 September 2020.
  42. Web site: Anon. 2012. Honour and heirloom for Sarah Teichmann . Laboratory of Molecular Biology . 2015-03-03. https://web.archive.org/web/20150303105307/http://www2.mrc-lmb.cam.ac.uk/honour-and-heirloom-for-sarah-teichmann/.
  43. Web site: 2022-08-26 . FEBS EMBO Women in Science Award - FEBS . 2024-01-04 . en-GB.
  44. Pain. Elisabeth. Harnessing computer power to understand biology. Science. 2015. 10.1126/science.caredit.a1500172.
  45. Book: Cornelsen English Library - Fiction: 8. Schuljahr, Stufe 1 - Teenage Detectives: Textheft. Mit Aufgaben und Activities. Teichmann. Sarah. Cornelsen Verlag. 1991. 978-3464053362. Germany. Teichmann. Virginia.
  46. Web site: The Honeycomb: Dr. Virginia Teichmann: Word Lover. 2015-12-07. expat-karlsruhe.com . Anon .

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