| Sapphawitthayakhom School | |
| Native Name: | โรงเรียนสรรพวิทยาคม |
| Address: | 51 Prasatwithi Rd. |
| City: | Mae Sot |
| Province: | Tak |
| Postcode: | 63110 |
| Country: | Thailand |
| Coordinates: | 16.7132°N 98.5731°W |
| Motto: | Kshanti hita sukhawaha |
| Other Name: | SW |
| Founder: | Pra Samaksapphakarn |
| Grades: | 7–12 (mathayom 1–6) |
| Teaching Staff: | 86 (130) |
| Enrollment: | 2,421 (2009 academic year) |
| Classes: | 56 |
| Type: | Public |
| School Board: | Tak Education Service Area Office 2 |
| Authority: | Office of the Basic Education Commission |
| Medium Of Language: | English and Thai |
| Director: | Somsak Letrattanapan |
| Song: | Marsh Sapphawitthayakhom |
| Colours: | Purple and yellow |
Sapphawitthayakhom School (th|โรงเรียนสรรพวิทยาคม) is a public school located in Mae Sot, Thailand. It admits secondary students (mathayom 1–6, equivalent to grades 7–12)). The school was founded on 30 November 1915. The student population is 2,500, with 120 staff, 97 of whom are teaching staff.
In upper-secondary there are six majors:
Sapphawitthayakhom school has run an international curriculum from grade 7 through grade 9 since 2010. In May 2012, Sapphawitthayakhom the school introduced a Mini English Program from Grade 7 through grade 10. All subjects are taught in English except Thai, Burmese and Chinese. The major English Subjects are: Computer, Physics, Core Maths, Biology, Chemistry, Astronomy, Social Studies, Health & Physical Education, Add Maths, Occupation & Technology.