| Santos Acosta | |
| Order: | 6th |
| Office: | President of the United States of Colombia |
| Predecessor: | Tomás Cipriano de Mosquera |
| Successor: | Santos Gutiérrez |
| Order2: | 8th President of the |
| Office2: | Sovereign State of Boyacá |
| Term Start2: | 1866 |
| Term End2: | 1868 |
| Predecessor2: | Sergio Camargo |
| Successor2: | Aníbal Correa |
| Birth Date: | 1 November 1828 |
| Birth Place: | Miraflores, Boyacá, Gran Colombia |
| Death Place: | Bogotá, Colombia |
| Birthname: | Manuel María de los Santos Acosta Castillo |
| Party: | Liberal |
| Spouse: | Carlota Larrota Castañeda |
| Alma Mater: | Our Lady of the Rosary University |
| Occupation: | Physician, soldier (General), politician, rector |
| Profession: | Physician |
| Allegiance: | Colombia (Liberal Party) |
| Branch: | National Army of Colombia |
| Serviceyears: | 1854–1876 |
| Commands: | Army Chief of Staff |
Manuel María de los Santos Acosta Castillo (November 1, 1828 – January 9, 1901) was a Colombian General and political figure. He served as the president of Colombia from 1867 until 1868.
Acosta was born in Miraflores, Boyacá, on November 1, 1828. He died in Bogotá on January 9, 1901.[1]
Although Acosta studied and graduated in medicine, he did not practice this profession. Rather, he pursued military and political careers. He was elected several times as MP, both to the House of Representatives and the Senate. Santos Acosta was one of the main players during the constitutional reform of 1853.[1]
In 1867, Congress elected Acosta as second Vice-President. Congress had also elected Santos Gutiérrez as first Vice-President and Joaquín Riascos as third Vice-President.[1]