| Santo Tomé Department | |
| Native Name: | Departamento Santo Tomé |
| Settlement Type: | Department |
| Coordinates: | -28.55°N -58°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Seat Type: | Seat |
| Seat: | Santo Tomé |
| Leader Title: | Mayor |
| Unit Pref: | Metric |
| Area Total Km2: | 7,359 |
| Population Total: | 54,050 |
| Population Density Km2: | auto |
| Population Demonym: | santotomeña/o |
| Postal Code Type: | Postal Code |
| Postal Code: | W3340 |
| Area Code Type: | Area Code |
| Area Code: | 03756 |
Santo Tomé Department is a department of Corrientes Province in Argentina.
The provincial subdivision has a population of about 54,050 inhabitants in an area of, and its capital city is Santo Tomé, which is located around from Capital Federal.