| Santo Tomé | |
| Native Name Lang: | es |
| Settlement Type: | City |
| Pushpin Map: | Argentina |
| Pushpin Label Position: | left |
| Pushpin Map Caption: | Location of Santo Tomé in Argentina |
| Coordinates: | -28.55°N -59°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | Santo Tomé |
| Leader Party: | Justicialist Party |
| Leader Title: | Mayor |
| Leader Name: | Carlos Raúl Farizano Artigas |
| Unit Pref: | Metric |
| Population Total: | 23,299 |
| Population As Of: | 2010 census |
| Population Density Km2: | auto |
| Population Demonym: | santotomeño |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | W3340 |
| Area Code Type: | Dialing code |
| Area Code: | +54 3756 |
Santo Tomé is a city in the province of Corrientes in the Argentine Mesopotamia. It had about 22,634 inhabitants at the . It is the head town of the department of the same name.
Santo Tomé was founded in 1632 by the Jesuit missionaries Luis Ernot and Manuel Bertot, with help from two native Guaraní chiefs that converted to Christianity. Its name is variedly found as Santo Tomás, Santo Tomás Apóstol, Santo Thomé and Santo Tomé.
The city lies in the north-east of the province, on the right-hand (western) shore of the Uruguay River, opposite the city of São Borja in Rio Grande do Sul, Brazil. The area has typical features of the Región Submisionera, with reddish soil, abundant flora and high lands, alternating with gray-soil lowlands and swamps.
The climate is subtropical, with average temperatures of 20 °C (the summer maximum is 40 °C, and winters are mild). The average annual rainfall is between 1,400 and 1,600 mm, peaking in April (autumn) and October (spring).