| Official Name: | Santo Domingo Xenacoj |
| Settlement Type: | Municipality |
| Pushpin Map: | Guatemala |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Guatemala |
| Subdivision Type: | Country |
| Subdivision Name: | Guatemala |
| Subdivision Name1: | Sacatepéquez Department |
| Leader Title: | Mayor |
| Unit Pref: | Imperial |
| Area Total Km2: | 19.3 |
| Population As Of: | 2018 census |
| Population Footnotes: | [1] |
| Population Total: | 12402 |
| Population Density Km2: | auto |
| Population Blank2 Title: | Religions |
| Coordinates: | 14.6822°N -90.7067°W |
| Elevation M: | 1832 |
| Blank Name: | Climate |
| Blank Info: | Cwb |
Santo Domingo Xenacoj is a town, with a population of 10,632 (2018 census),[2] and a municipality in the Guatemalan department of Sacatepéquez.
The native term Xenacoj has been evolving over the centuries: in 1625, Irish friar Thomas Gage, call it Sinacao; later, friar Francisco Ximenes, O.P. in 1717, calls it Xencoc. In the San Pedro documents is shown as Senacoc and in 1806 was written as Xinacó, in 1880 as Xinacó and, finally, in the early 20th century is written as Xenacoj. The origin of the name comes from the word "Xe" which means under or beneath and Nacoj, which is the name of a hill; therefore, the name Xenacoj means "under the Nacoj hill". Another version claims that instead of Hill, Na means mouth and Coj means lion.
Santo Domingo Xenacoj is located in a valley that the Spanish conquistadores called "de Sacatepéquez" (English: Valle of Sacatepéquez) in the 1520s. That valley was bordered by the valley of Xilotepeque on the West, those of Mixco and las Vacas on the North, and by the Chiquimula province and the South and East. The town was described as having "warm climate" by Irish friar Thomas Gage in his 1648 book about his travels through America in the 1620s and 1630s.
Historian Domingo Juarros wrote that in 1766 the Chimaltenango and Sacatepéquez municipalities tried to join, but it did not work out and they remained split until after independence from Spain in 1821.
Santo Domingo Xenacoj has a subtropical highland climate (Köppen: Cwb).