| Santo Domingo Tlatayápam | |
| Settlement Type: | Municipality and town |
| Pushpin Map: | Mexico |
| Pushpin Label Position: | above |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Oaxaca |
| Area Total Km2: | 12 |
| Population As Of: | 2010 |
| Population Total: | 153 |
| Population Urban: | 147 |
| Timezone: | Central Standard Time |
| Utc Offset: | -6 |
| Timezone Dst: | Central Daylight Time |
| Utc Offset Dst: | -5 |
| Coordinates: | 17.4067°N -97.3461°W |
| Elevation M: | 2248 |
Santo Domingo Tlatayápam is a village and small municipality in Oaxaca in south-western Mexico. The municipality covers an area of 12 km². It is part of the Teposcolula District in the center of the Mixteca Region
As of the 2010 census, the village had a population of 147 inhabitants, while the municipality had a total population of 153 inhabitants.[1] It is the third-smallest municipality in Mexico in population (following Santa Magdalena Jicotlán and Santiago Tepetlapa, both also in Oaxaca).