| Santo Domingo | |
| Settlement Type: | Municipality |
| Pushpin Map: | Nicaragua |
| Pushpin Label Position: | right |
| Pushpin Mapsize: | 250 |
| Pushpin Map Caption: | Location in Nicaragua |
| Subdivision Type: | Country |
| Subdivision Name: |  Nicaragua |
| Subdivision Type1: | Department |
| Subdivision Name1: | Chontales Department |
| Unit Pref: | Imperial |
| Area Total Km2: | 717 |
| Population As Of: | 2005 |
| Population Total: | 12182 |
| Population Density Km2: | auto |
| Population Urban: | 3309 |
| Coordinates: | 12.25°N -89°W |
Santo Domingo is a municipality in the Chontales Department of Nicaragua. It has a population of 14,343, with about half of the population living in an urban zone.