| Santo Antônio das Missões | |
| Settlement Type: | Municipality |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Location in Brazil |
| Coordinates: | -28.5108°N -55.2278°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Brazil |
| Subdivision Type1: | State |
| Subdivision Name1: | Rio Grande do Sul |
| Subdivision Type2: | Meso-region |
| Subdivision Name2: | Noroeste Rio-Grandense --> |
| Subdivision Type3: | Micro-region |
| Subdivision Name3: | Santo Ângelo |
| Leader Title: | Prefect |
| Area Total Km2: | 1710.87 |
| Population Total: | 10,050 |
| Population As Of: | 2020 [1] |
| Population Density Km2: | auto |
| Timezone1: | BRT |
| Utc Offset1: | -3 |
| Postal Code Type: | Postal code |
| Area Code Type: | Phone code |
Santo Antônio das Missões (Portuguese meaning "Saint Anthony of the missions") is a municipality in the western part of the state of Rio Grande do Sul, Brazil. The population is 10,050 (2020 est.) in an area of 1710.87 km2.[2] Distance from the state capital of Porto Alegre is 534 km west and tens of kilometres east from the Argentine border but the municipality does not border since it is close.
The municipality would be partially flooded by the proposed Garabí Dam.