| Official Name: | Santo Antônio |
| Settlement Type: | Municipality |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Brazil |
| Subdivision Type: | Country |
| Subdivision Name: |  Brazil |
| Subdivision Name1: | Nordeste |
| Subdivision Type2: | State |
| Subdivision Name2: | Rio Grande do Norte |
| Subdivision Type3: | Mesoregion |
| Subdivision Name3: | Agreste Potiguar |
| Subdivision Type4: | Microregion |
| Subdivision Name4: | Agreste Potiguar |
| Area Total Km2: | 301.05 |
| Population As Of: | 2020 [1] |
| Population Total: | 24,280 |
| Population Density Km2: | auto |
| Timezone: | BRT |
| Utc Offset: | -3 |
| Coordinates: | -6.311°N -35.48°W |
Santo Antônio (Portuguese for "Saint Anthony") is a municipality (município) in the state of Rio Grande do Norte in Brazil. The population in 2020 was 24,280 and the area is 301 km2. The elevation is 92 m.