| Santillane | |
| Designated Other1: | Virginia Landmarks Register |
| Designated Other1 Date: | January 15, 1974[1] |
| Designated Other1 Number: | 011-0032 |
| Designated Other1 Num Position: | bottom |
| Coordinates: | 37.4936°N -79.8811°W |
| Architecture: | Greek Revival |
| Added: | July 24, 1974 |
| Refnum: | 74002107 |
Santillane is a historic home located near Fincastle, Botetourt County, Virginia. It was built in 1795, and consists of a two-story high, three bay by four bay, main block with a one-story, rear kitchen wing. It is constructed of brick and is in the Greek Revival style. The house has a shallow hipped roof and tetrastyle two-story front portico dated to the early 20th century. Also on the property is a contributing stone spring house. The house stands on a tract purchased by Colonel George Hancock (1754–1820) in 1795. The kitchen wing may date to his period of ownership.[2] It was listed on the National Register of Historic Places in 1974.