| Settlement Type: | Municipality |
| Flag Size: | 150 |
| Subdivision Type: | Country |
| Subdivision Name: | Spain |
| Subdivision Type1: | Autonomous community |
| Subdivision Name1: | Castile and León |
| Subdivision Type2: | Province |
| Subdivision Name2: | Salamanca |
| Subdivision Type3: | Comarca |
| Subdivision Name3: | Tierra de Peñaranda |
| Population Density Km2: | auto |
| Timezone: | CET |
| Utc Offset: | +1 |
| Timezone Dst: | CEST |
| Utc Offset Dst: | +2 |
| Official Name: | Santiago de la Puebla |
| Leader Title: | Alcalde (Mayor) |
| Leader Name: | Casimiro García Pérez (2011) |
| Leader Party: | PSOE |
| Area Footnotes: | [1] |
| Area Total Km2: | 53 |
| Elevation M: | 867 |
| Coordinates: | 40.4686°N -5.0286°W |
| Blank Name Sec1: | Official language(s) |
| Postal Code Type: | Postal code |
| Postal Code: | 37311 |
| Area Code Type: | Dialing code |
| Area Code: | 923 |
Santiago de la Puebla is a village and municipality in the province of Salamanca, western Spain, part of the autonomous community of Castile-Leon. It is located 54 kilometres from the provincial capital city of Salamanca and has a population of 417 people.
The municipality covers an area of 53 km². It lies 824 metres above sea level.
The economy is based primarily on agriculture and olive growing.