| Official Name: | Santiago de Machaca |
| Settlement Type: | Municipality |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location within Bolivia |
| Subdivision Type: | Country |
| Subdivision Type1: | Department |
| Subdivision Name1: | La Paz Department |
| Subdivision Type2: | Province |
| Subdivision Name2: | José Manuel Pando Province |
| Seat Type: | Seat |
| Leader Title: | Mayor |
| Leader Title1: | President |
| Established Title: | Foundation |
| Unit Pref: | Imperial |
| Population As Of: | 2001 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Timezone: | BOT |
| Utc Offset: | -4 |
Santiago de Machaca is the first municipal section of the José Manuel Pando Province in the La Paz Department, Bolivia. Its seat is Santiago de Machaca.