| Official Name: | Santiago de Machaca |
| Settlement Type: | Town |
| Pushpin Map: | Bolivia |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location within Bolivia |
| Subdivision Type: | Country |
| Subdivision Type1: | Department |
| Subdivision Name1: | La Paz Department |
| Subdivision Type2: | Province |
| Subdivision Name2: | José Manuel Pando Province |
| Subdivision Type3: | Municipality |
| Subdivision Name3: | Santiago de Machaca Municipality |
| Leader Title: | Mayor |
| Leader Title1: | President |
| Established Title: | Foundation |
| Unit Pref: | Imperial |
| Population As Of: | 2001 |
| Population Footnotes: | [1] |
| Population Total: | 819 |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Timezone: | BOT |
| Utc Offset: | -4 |
| Coordinates: | -17.0667°N -81°W |
Santiago de Machaca is a location in the La Paz Department in Bolivia. It is the seat of the Santiago de Machaca Municipality, the first municipal section of the José Manuel Pando Province, and it is also the seat of the province.