| Santiago Tepetlapa | |
| Settlement Type: | Municipality and town |
| Pushpin Map: | Mexico |
| Pushpin Label Position: | above |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Oaxaca |
| Leader Name: | President known as of 2012 is Heladio Montalban De La Rosa |
| Population As Of: | 2010 |
| Population Total: | 131 |
| Population Urban: | 101 |
| Timezone: | Central Standard Time |
| Utc Offset: | -6 |
| Timezone Dst: | Central Daylight Time |
| Utc Offset Dst: | -5 |
| Coordinates: | 17.7819°N -97.4008°W |
| Elevation M: | 2172 |
Santiago Tepetlapa is a town and municipality in Oaxaca, in southwestern Mexico. The municipality has an area of 13.624 km² and is part of the Coixtlahuaca district in the Mixteca Region.
As of the 2010 census, the town (locality) had a population of 101 inhabitants, while the municipality had a total population of 131 inhabitants.[1] It is the second-smallest municipality in Mexico in population, larger than only Santa Magdalena Jicotlán, also in Oaxaca.