| Santiago Nejapilla | |
| Settlement Type: | Municipality and town |
| Native Name: | Santiago Nejapilla |
| Pushpin Label Position: | above |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Oaxaca |
| Population As Of: | 2005 |
| Timezone: | Central Standard Time |
| Utc Offset: | -6 |
| Timezone Dst: | Central Daylight Time |
| Utc Offset Dst: | -5 |
| Elevation M: | 2255 |
| Elevation Ft: | 7398 |
| Official Name: | Santiago Nejapilla |
| Elevation Min M: | 2,211 |
| Elevation Max M: | 2,824 |
| Elevation Min Ft: | 7253 |
| Elevation Max Ft: | 9268 |
Santiago Nejapilla is a town and municipality in Oaxaca in south-western Mexico.It is part of the Teposcolula District in the center of the Mixteca Region
The municipality of Santiago Nejapilla has a population of less than 500 people.