| Santiago Matatlán | |
| Settlement Type: | Municipality and town |
| Nickname: | World Capital Of Mezcal |
| Pushpin Map: | Mexico#Mexico Oaxaca |
| Pushpin Label Position: | above |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Oaxaca |
| Population As Of: | 2005 |
| Timezone: | Central Standard Time |
| Utc Offset: | -6 |
| Timezone Dst: | Central Daylight Time |
| Utc Offset Dst: | -5 |
| Coordinates: | 16.8667°N -119°W |
Santiago Matatlán a.k.a. "World Capital Of Mezcal" is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of 85.48 km2.
It is part of the Tlacolula District in the east of the Valles Centrales Region.